LubriLAST™

Lubricious Hydrophilic Coating

LubriLAST™ coatings are

Lubricious:

LubriLAST™ coatings virtually eliminate coefficient of friction in aqueous environments.

Aqueous:

LubriLAST™ coatings contain no organic solvents. Safer and cleaner manufacturing processes are used, and any concerns about residual solvents in a device are eliminated.

Durable:

LubriLAST™ retains it’s physical integrity and lubricity even after hundreds of cycles.

Biocompatible:

LubriLAST™ passes all stringent biocompatibility tests associated with tissue and blood contacting devices.

Flexible:

LubriLAST™ withstands use in the tortuous paths found in physiological systems without flaking or delamination. It can be applied to balloons used in a number of medical applications.

Accepted:

LubriLAST™ is patent protected (US#6,238,799; US#6,866,936) and used in a number of approved devices used in neurovascular, cardiovascular, urological, and surgical applications.

How does LubriLAST™ work?

In LubriLAST™, a long chain, biocompatible hydrophilic polymer is incorporated into the coating. Part of this long hydrophilic polymer becomes entangled with the supporting network while other part remains exposed and able to become hydrated. When in the presence of water or body fluids, the hydrophilic polymer adsorbs water molecules to create a watery interface at the surface of the device. The water cushion reduces wet friction, protein adsorption and cell adhesion.

Friction Reduction

Coefficient of friction comparisons*

Surface Coefficient of Friction
Static  Kinetic
Uncoated PE 5.890  1.019
Uncoated PET 0.328  1.291
PET, Silicone coated 0.041  0.021
LubriLAST™ coated PE T.009  <0.00

* Data developed via modified D-1894-95 protocol. Test performed in water, samples pulled against polyethylene.

Relative friction reduction for various substrates

Durability

Biocompatibility

Tissue Biocompatibility

  • Cytotoxicity
  • Sensitization tests in guinea pigs
  • Acute intracutaneous reactivity
  • Pyrogen material mediated test
  • Systemic toxicity

Hemocompatibilty

  • Direct Hemolysis
  • In vivo thrombogenic resistance study
  • Complement activation
  • Coagulation study

Sterilization and Shelf Life

Medical devices coated with LubriLAST™ can be sterilized by:

  • ETO
  • Gamma
  • E-beam
  • Shelf life: LubriLAST™ sterilized products have a shelf life of 3 years
How does LubrLAST work?
LubriLAST™ is part of the BioLAST technology platform. The supporting polymer network characteristic to BioLAST is crosslinked and covalently bound to the substrate. This network is normally non-swellable in water. In LubriLAST™, a long chain, biocompatible hydrophilic polymer is incorporated into the coating. Part of this long hydrophilic polymer becomes entangled with the supporting network while other part remains exposed and able to become hydrated. When in the presence of water or body fluids, the hydrophilic polymer adsorbs water molecules to create a watery interface at the surface of the device. The water cushion reduces wet friction, protein adsorption and cell adhesion.