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Hydrophilic Medical Coating - HyrdroLAST

HydroLAST™ Hydrophilic Surface Treatment & Medical Device Coating

Hydrophilic Surface Treatment

HydroLAST™ coatings are:

Hydrophilic:                                                                    Stable:

HydroLAST™ coatings improve the wettability and wicking                             HydroLAST™ remains effective with pH levels ranging from 2 to 13
of most polymeric biomaterials.                                                                         for at least 1 year in ambient storage environments.

Thin:                                                                                   Biocompatible:

HydroLAST™ coatings are sub-micron in thickness. They                                HydroLAST™ is non-toxic as concluded through test methods
do not alter mechanical or optical properties.                                                  based on USP XXII.

Accepted:                                                                          Reactive:

Covered by U.S. patents 5,700,559; 5,807,636; and 5,837,377;                      HydroLAST™ coatings contain abundant hydrophilic functional HydroLAST™ is accepted for use in surgical devices,                                       groups that can include hydroxil, carboxyl, or amine     
wicking components of diagnostics, battery separators,                                  functionalities. These reactive sites can be further derivatized
and microplates.                                                                                                  for protein or ligand immobilization.

 

How does HydroLAST™ work?

HydroLAST™ is a process by which hydrophilic polymers are grafted permanently to the surface of a hydrophobic substrate. The hydrophilic polymer has carboxyl, hydroxil, or amine functionalities that serve to loosely bind water. Once treated, the substrate “wets out” and allows water and reagents to flow easily over or through it (in the case of porous substrates). Unlike conventional hydrophilic treatments such as straight plasma, corona, or ozone processing, the surface is permanently hydrophilic rather than transiently. Greater assay accuracies can be achieved, higher throughputs can be realized, and diagnostic process automation can be accomplished.

Enhanced Hydrophilic Properties

HydroLAST™ Treated Sample of Polyethylene Readily Wicks Water. Water Contact Angle Reduced To Zero After Processing.

The photograph on the right illustrates the enhanced hydrophilicity imparted to ultra-high molecular weight polyethylene (UHMWPE) by HydroLAST™. The untreated control does not wick any water. The oxygen treated sample shows some wicking, while the HydroLAST™ treated sample readily wicks water. In many cases, the water contact angle is reduced to zero after processing. This property is important in many diagnostic and medical device applications. Enhanced hydrophilicity is important in industrial applications where restriction of fluid flow creates problems. Examples include battery separators and printing applications.

Stability

The graph below illustrates the stability of HydroLAST™. After 90 days of repeated sonication, the water contact angle of treated ultra-high molecular weight polyethylene (UHMWPE) remains at zero. Within a few days, oxygen plasma treated UHMWPE has become essentially hydrophobic with a water contact angle of more than 70. Shortly thereafter, the contact angle approaches that of the control, namely, a very hydrophobic 120. At pH levels ranging from 2 to 13 and at elevated temperatures, HydroLAST™ exhibited far superior stability as compared to that of conventional plasma or corona surface treatments.

Water Contact Angle of Ultra-High Molecular Weight Polyethylene Treated with HydroLAST™ Remains at Zero, Even After 90 Days of Repeated Sonication.

Biocompatibility and Sterilizability

HydroLAST™ treated parts can be sterilized by gamma and e-beam sterilization. It is non-toxic and has passed cytotoxicity, direct hemolysis, systemic toxicity, all other biocompatibility tests associated with blood contact devices.

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