Lubricious & Hydrophilic Medical Coating - LubriLAST
Lubricious Hydrophilic Coating
LubriLAST™ coatings are:
LubriLAST™ coatings virtually eliminate coefficient LubriLAST™ coatings contain no organic solvents. Safer and
of friction in aqueous environments. cleaner manufacturing processes are used, and any concerns
about residual solvents in a device are eliminated.
LubriLAST™ retains it’s physical integrity and lubricity LubriLAST™ passes all stringent biocompatibility tests associated
even after hundreds of cycles. with tissue and blood contacting devices.
LubriLAST™ withstands use in the tortuous paths found LubriLAST™ is patent protected (US#6,238,799; US#6,866,936)
in physiological systems without flaking or delamination. and used in a number of approved devices used in
It can be applied to balloons used in a number of medical neurovascular, cardiovascular, urological, and surgical applications. applications.
How does LubriLAST™ work?
In LubriLAST™, a long chain, bio-compatible hydrophilic polymer is incorporated into the coating. Part of this long hydrophilic polymer becomes entangled with the supporting network while other part remains exposed and able to become hydrated. When in the presence of water or body fluids, the hydrophilic polymer adsorbs water molecules to create a watery interface at the surface of the device. The water cushion reduces wet friction, protein adsorption and cell adhesion.
Coefficient of friction comparisons*
Surface Coefficient of Friction
Uncoated PE 5.890 1.019
Uncoated PET 0.328 1.291
PET, Silicone coated 0.041 0.021
LubriLAST™ coated PET .009 <0.00
* Data developed via modified D-1894-95 protocol. Test performed in water, samples pulled against polyethylene.
Relative friction reduction for various substrates
LubriLAST™ Durability Results After 300 Cycles in Push/Pull Tests:
- Sensitization test in guinea pigs
- Acute intracutaneous reactivity
- Pyrogen material mediated test
- Systemic toxicity
- Direct Hemolysis
- In vivo thrombogenic resistance study
- Complement activation
- Coagulation study
Sterilization and Shelf Life
Medical devices coated with LubriLAST™ can be sterilized by:
- Shelf life: LubriLAST™ sterilized products have a shelf life of 3 years